This cookie is set by GDPR Cookie Consent plugin. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". The _hssrc cookie set to 1 indicates that the user has restarted the browser, and if the cookie does not exist, it is assumed to be a new session. This cookie is set by Hubspot whenever it changes the session cookie. These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. Aggregation is indicated by peaks to the right of those observed in the buffer blank. Dynamic Light Scatteringįigure A: DLS data for a compound at aggregating and sub-aggregating concentrations, illustrating the raw correlation functions (left) and the corresponding intensity distribution (right). The correlation between time points is used to determine the radii of nanometre-scale objects in solution. Preformulation and Formulation Developmentĭynamic light scattering (DLS) is a Biophysical Technique that enables particles to be distinguished on the basis of their size. Sygnature have experience in the utilisation of this technique using the Viscotek DLS reader, to interrogate the stoichiometry of protein-protein interactions and to identify aggregating compounds or non-specific inhibitors, adding value to our client’s discovery programs via hit validation, protein characterisation and assay troubleshooting.ĭLS enables an assessment of compound, protein or protein-ligand binding complex aggregation behaviour by measuring the correlation between the intensity of scattered light over a time course.Metabolite Drug Identification (Met-ID).Fluorescent Thermal Shift Assays (FTSA).Cellular interaction and Co-Culture Assay Systems.
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